Answer:
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) involves the continued secretion or action of arginine vasopressin (AVP) despite normal or increased plasma volume. The resulting impairment of water secretion and consequent water retention produces the hyponatremia (ie, serum Na+ < 135 mmol/L) with concomitant hypo-osmolality (serum osmolality < 280 mOsm/kg) and high urine osmolality that are the hallmark of SIADH. [1] The key to understanding the pathophysiology, signs, symptoms, and treatment of SIADH is the awareness that the hyponatremia results from an excess of water rather than a deficiency of sodium.
Signs and symptoms of SIADH
Depending on the magnitude and rate of development, hyponatremia may or may not cause symptoms. The history should take into account the following considerations
Explanation:
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