In female mammalian cells, one X chromosome of the two would undergo random inactivation early in embryonic life, and therefore both males and females have a single active Y. with this the disease has a predilection in men because women do not carry the Y gene
Recessive lethal alleles cause death when they are homozygous. Death occurs at the stage when the product of this gene is needed. If the gene in question is responsible for the synthesis of a particular protein in early childhood, for example, the organism will die at that moment.
With this information, we can conclude that Y chromosome, is what guarantees the development of a male embryo and the lethal “b” allele
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