Respuesta :
Linear fixed model is a statistical model that includes both fixed effects and random effects is known as a mixed model, mixed-effects model, or mixed error-component model. These models have applications in a wide range of fields in the physical, biological, and social sciences.
How do you perform a genome scan with a linear mixed model?
Mice genetic mapping provides a superb illustration of the value of population structure. The tiny number of founders (fancy mice) from whom laboratory mouse strains originated led to many population bottlenecks. The history of wild-derived strains differs from that of laboratory strains since they are not descended from fancy mice. In order to tackle relatedness between people and population structure issues brought on by varying ancestries, linear mixed models were devised. In order to account for population structure, known kinship, and unknowable relatedness, linear mixed models (LMMs) take genome-wide similarity between all pairings of individuals into consideration. By include kinship in the model, linear mixed models in mapping studies can successfully adjust for genetic relatedness between individuals in a population.
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