Respuesta :
A sizable, distinctive database is created that contains information on 2124 individuals with myelodysplastic syndromes (MDSs) from 4 institutions in Austria and 4 in Germany. This information comprises morphologic, clinical, cytogenetic, and follow-up data. 1084 (52.3%) of the 2072 patients with successfully completed cytogenetic tests had clonal abnormalities. Each patient's chromosomal structural and numerical anomalies were recorded, and the number of additional abnormalities was divided further. As a result, 684 distinct cytogenetic classifications were found. 1286 patients who received only supportive care were used to study how the karyotype affected the disease's natural course. Patients with normal karyotypes had a median life of 53.4 months (n = 612) while those with complicated abnormalities had a median survival of 8.7 months (n = 166).
A total of 13 uncommon abnormalities were found, each with a different prognostic impact: good (+1/+1q, t(1q), t(7q), del(9q), del(12p), chromosome 15 anomalies, t(17q), monosomy 21, trisomy 21, and -X), intermediate (del(11q), chromosome 19 anomalies), or poor (t(5q)). Depending on the chromosomes involved, other anomalies have varying prognostic significance. The karyotype added extra prognostic information for all WHO and French-American-British (FAB) classification system subtypes. Our studies shed fresh light on the importance of rare chromosomal aberrations and particular karyotypic combinations in MDS for prognosis.
What are myelodysplastic syndromes?
A set of malignancies known as myelodysplastic syndromes (also known as myelodysplasia) prevent your blood stem cells from developing into healthy blood cells. Serious diseases include anemia, frequent infections, and bleeding that won't stop can be brought on by myelodysplastic syndromes.
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