Respuesta :
Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway Blockade of EGFR by EGFR tyrosine kinase inhibitors such as erlotinib is insufficient for effective treatment of human pancreatic cancer due to independent activation of the Akt pathway,
What is Amiloride ?
Amiloride, which is marketed under the brand names Midamor among others, is frequently used with other drugs to treat excessive blood pressure, edema brought on by heart failure, or liver cirrhosis. Amiloride is categorized as a diuretic that conserves potassium. A thiazide or loop diuretic, for example, is a type of additional diuretic that is frequently used with amiloride. It is consumed orally. The duration of the action, from when it begins to end, is around two hours.
High blood potassium levels, nausea, lack of appetite, rash, and headache are typical adverse reactions. People with diabetes, kidney disease, and those who are older are more at risk for having high blood potassium levels. The epithelial sodium channel (ENaC) in the late distal tubule, which connects tubules, is blocked by amiloride.
To learn more about Amiloride from the given link:
https://brainly.com/question/25719819
#SPJ4
