Aspirin produces most of its analgesic effects by inhibiting the synthesis of prostaglandins.
Aspirin, also called acetylsalicylic acid, is a medication used to reduce pain, fever and inflammation.
Prostaglandins are unsaturated carboxylic acids, containing a 20 carbon skeleton that also has a five member ring. They are biochemically manufactured from arachidonic acid.
Aspirin obstructs an enzyme called cyclooxygenase, COX-1 and COX-2, that is linked with the ring closure and addition of oxygen to arachidonic acid converting to prostaglandins.
By obstructing this enzyme, the synthesis of prostaglandins is inhibited which in turn relieves some of the effects of pain and fever. Aspirin is also believed to inhibit the prostaglandin synthesis involved with unwanted blood clotting in coronary heart disease.
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