The ends of the actin filaments are anchored to the Z-line or disk.
The sarcomere is the primary functional unit of muscle fiber. It is flanked by a Z-band on each end with adjoining I-bands. The Z-band or disk is a dense fibrous structure composed of actin, α-actinin as well as other proteins.
Thin filaments or actin filaments are anchored at one end at the Z-band. Titin is connected to both the Z-band and the M-line. Thick filaments are attached in the middle of the sarcomere at the M-line.
An intermediary filament protein forms a meshwork from one Z-disk to the next across the myofibril. These networks are joined by actin through the protein dystrophin to the sarcolemma.
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