Respuesta :
The glycolytic reaction catalyzed by pyruvate kinase is bypassed in gluconeogenesis by using two enzymes.
The process through which glucose is produced from non-carbohydrate precursors is termed as gluconeogenesis. The bypassing of the glycolytic step catalyzed by pyruvate kinase is in fact, achieved by a two-step process catalyzed by two different enzymes i.e. pyruvate carboxylase and phosphoenolpyruvate carboxy kinase (PEPCK).
The first step requires pyruvate to undergo carboxylation thereby, forming oxaloacetate. This reaction is driven at the expense of a high-energy phosphate bond of ATP.
The second step includes conversion of oxaloacetate to phosphoenolpyruvate (PEP) which also requires energy; only this time high-energy phosphate bond of GTP is used for the purpose.
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