Respuesta :
Suppression of self-reactive t cells, by direct and indirect interactions between the tregs and activated immune cells is one mechanism for peripheral t cell tolerance.
The second branch of immunological tolerance after central tolerance is peripheral tolerance. It occurs in the peripheral immune system (after T and B cells egress from primary lymphoid organs). Its main goal is to prevent the development of autoimmune illness from self-reactive T and B cells that eluded central tolerance. Immune reactions to both allergens and innocuous dietary antigens are prevented by peripheral tolerance.
Peripheral tolerance is mediated by methods that are antigen-specific, such as persistent T cell quiescence, antigen ignorance, and direct inactivation of effector T cells through clonal deletion, Treg conversion, or induction of anergy. Foxp3 is the principal controller of Treg phenotype and activity. During the negative selection, natural Tregs (nTregs) are produced in the thymus.
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