proton pump inhibitors verus histamine 2 receptor antagonists for stress ulcer prophylaxis in patients with sepsis

Question

09-08-2022
Biology

contestada

proton pump inhibitors verus histamine 2 receptor antagonists for stress ulcer prophylaxis in patients with sepsis

Respuesta :

Otras preguntas

1. Explain why the Nuremberg and Tokyo trials were held and the precedent these trials established for future responses to war crimes.

What was the United States' principal use of Guam in the late 19th century and early 20th century?

Messenger RNA carries a(n) ___________ of the DNA’s instructions out of the nucleus to the ___________. a. exact copy; ribosome b. transcript; ribosome c. ex

When we want to know who has sovereignty, we want to know who has __________.

What possessive adjective goes with the sentence: soeurs vont à la plage. (his)

Why did Albert Einstein leave Germany? a. because his scientific experiments were continually disproved b. because he was a member of the then out-of-power Na

How did Latin Americans view wilson's moral imperialism?

Julian and stacey needed 10 liters of water to fill a tank. Stacey filled the tank with 3 11/12 liters of water. Julian poured 1 2/5 liters less than Stacey int

What do people mean with " No one can do everything but everyone can do something"??

Stress surrounds us on a daily basis. Which of the following statements BEST describes ways to reduce or handle stress? a. Handling stress effectively involves

tutorconsortium202 tutorconsortium202 · Answer 1 · 2022-08-13T11:00:37+02:00

Critically ill patients admitted to the intensive care unit (ICU) are at risk of developing gastrointestinal (GI) bleeding owing to stress ulcers, which is associated with a prolonged length of stay (LOS) in the ICU and an increased risk of death.

To prevent GI bleeding in these critically ill patients, ICU doctors frequently prescribe stress ulcers prophylaxis (SUP).
Proton pump inhibitors (PPIs) and histamine type 2 receptor blockers (H2Bs) are the most commonly used SUP agents.
Sepsis has been considered a risk factor for the development of stress ulceration and GI bleeding for many years, and SUP is recommended by the Surviving Sepsis Campaign guidelines for patients with sepsis or septic shock who have risk factors for GI bleeding.
Although these guidelines further recommend either H2Bs or PPIs when SUP is indicated, there is limited evidence of the effects of H2Bs in comparison with PPIs when used as SUP in critically ill patients with sepsis.
A recent meta-analysis of a general population of patients in the ICU suggested that PPIs are the most effective agents in preventing clinically important GI bleeding. However, two retrospective studies found that PPIs were associated with a higher rate of GI bleeding than H2Bs.
In clinical practice, PPIs are more commonly prescribed by critical care providers, possibly because of their superior acid suppression capability in comparison with H2Bs.
However, PPI use is not without risk. Some studies have shown that patients receiving PPIs have a higher risk of nosocomial pneumonia, Clostridium difficile infection(CDI), and myocardial infarction.
Accordingly, it is reasonable to evaluate the comparative effects of SUP using PPIs and H2Bs on important outcomes in patients with severe sepsis or septic shock.
A retrospective cohort study compares two strategies for SUP among adult patients with sepsis or septic shock who have risk factors for GI bleeding.
Specifically, hypothesized that PPIs are associated with a lower occurrence of GI bleeding and in-hospital mortality than H2Bs but may increase the risk of pneumonia and CDI.

To learn more about Proton pump inhibitors: https://brainly.com/question/15605049

#SPJ4