Respuesta :
How photoreceptor degeneration begin in rd mouse?
- A mutation in the rod-specific enzyme cGMP phosphodiesterase causes photoreceptor degeneration in the rd/rd animal.
- As a result, the rod outer segment membrane's cGMP-gated cation channels are permanently opened, allowing Na(+) and Ca(2+) ions to enter the cell and potentially lethal quantities of Ca(2+).
- When being compared gene expression in the rd/rd and wild type (wt) mice retinas using U74A oligonucleotide arrays (Affymetrix)
- During the recognized time period of photoreceptor degeneration in order to discover pathways implicated in cell death of the rd/rd rods.
- By postnatal day 10, gene expression in rd/rd began to differ from wt.
- The decrease in photoreceptor-specific genes coincided with the recognized progression of photoreceptor aging.
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