The biggest lifetime doses of ionizing radiation are often caused by high Linear Energy Transfer (high-LET) alpha particles, which are produced by the radioactive decay of radon gas in indoor air. Environmental radiation exposure is common. The DNA damage caused by particle radiation, which includes oxidative base lesions and DNA double strand breaks, is extremely genotoxic.
Radiation-Induced Oxidative and Clustered DNA Damage
- Ionizing radiation (IR) exposure is common among people, with 85% of it coming from natural sources.
- For the average human, radioactive radon gas and its offspring that produce alpha particles, which come from the earth and are frequently concentrated to high levels in the built environment, account for 40% to 45% of lifetime infrared exposure.
- Individual radon exposure can vary greatly and is influenced by a variety of factors, including geography, human behavior, psychosocial issues, and the characteristics of a particular building.
- The disintegration of radioactive elements releases alpha particles, which have the same mass as a helium nucleus and are made up of two neutrons and two protons.
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