Yes, the beneficiary's principal diagnosis and how many secondary diagnoses may include comorbidities or complications determine the DRG assignment.
DRG assignment is defined based on the treated patient's primary diagnosis, secondary diagnosis, surgical procedure, age, sex, and discharge status. The DRG assignment gives hospitals an overview of the patients treated, the costs incurred, and the expected services required within reason.
There are currently three main versions of the DRG assignment in use: Basic DRG, All Patient DRG, and All Patient Refined DRG. Base DRGs are used by Medicare and Medicaid Service Centers (CMS) to pay hospitals for Medicare beneficiaries.
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