They used they're religion as a main a belief. The spread of smallpox put a halt on Americas conquest.The Spainish soldiers and sailors and more advanced weapon art then the inidians so the succeeded in over powering them. They also made alliances with some of the native Americans and also become enemies with the Incad and Aztecs.They also had some of the most advanced sea navigating technology of they're time. They were also extremely motivated in finding gold and a route to Asia