Overproduction of adrenocortical hormones, mainly cortisol or related corticosteroids, as well as to a lesser extent androgens and aldosterone, results in Cushing's Disease (also known as Hypercortisolism, Adrenal Hyperfunction, or Cushing's Syndrome). The disorder is brought on by benign or malignant adrenal tumors that release too many glucocorticoids into the blood, prolonged or excessive corticosteroid administration, and adrenocortical hyperplasia (overgrowth of the adrenal cortex) secondary to pituitary overproduction of adrenocorticotropic hormone (ACTH). Modified fat distribution, a weakened immune system, issues with protein metabolism, and fluid and electrolyte imbalances are all side effects of the condition.
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