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Examine the data shown in Figures 2 and 3. Carefully compare the DNA methylation profiles from the 3-year-old twins versus the 50-year-old twins and summarize your observations. Which set of twins (3-year-old or 50-year-old) have the most similar DNA methylation profiles? Provide a brief explanation of your observations.

Examine the data shown in Figures 2 and 3 Carefully compare the DNA methylation profiles from the 3yearold twins versus the 50yearold twins and summarize your o class=
Examine the data shown in Figures 2 and 3 Carefully compare the DNA methylation profiles from the 3yearold twins versus the 50yearold twins and summarize your o class=

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bharathparasad577

A DNA base is altered biochemically during DNA methylation, which typically takes place during gametogenesis and after fertilization.

  • The DNA methyltransferases DNMT1, DNMT3A, and DNMT3B keep methylation marks in tact after each cell division.
  • Although the majority of methylation marks are stable, there is typically 10% to 20% variation over time. Ly cytosine undergoes enzymatic 5-carbon methylation.
  • DNA methylation represents the best characterized form of epigenetic modification. DNA methylation is written onto the genome by two methyltransferases, known as Dnmt3a and Dnmt3b.
  • These enzymes catalyze the addition .
  • Aging is often marked by the establishment of global hypomethylation and regions of CpG island hypermethylation.
  • These changes in the epigenetic landscape may contribute to aging by adversely affecting genomic stability and gene regulation.
  • Thus, DNA methylation has its affect on aging and thus should be observed carefully.

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