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The gene that causes sickle cell disease is present in a higher percentage of residents of sub-Saharan Africa than among those of African descent living in the United States. This gene provides some protection from malaria, a serious disease that is widespread in sub-Saharan Africa. Discuss an evolutionary process that could account for the different percentages among residents of the two regions. (See Concept 1.2 .)

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The evolutionary process that accounts for the different sickle cell allele ratios is stabilizing selection in endemic malaria areas.

What is stabilizing selection?

Stabilizing selection is a special class of natural selection that acts to maintain the frequency of a harmful allele in the population because it confers some type of adaptive advantage to the individuals in the population.

In this case, the allele for sickle-cell anemia can be harmful when it is homozygous individual but it is beneficial in heterozygous individuals because it allows them to resist malaria disease, and therefore this allele is maintained by a special class of stabilizing selection on the population.

In conclusion, the evolutionary process that accounts for the different hemoglobin allele ratios in the two world regions may be associated with the different types of natural selection (i.e., stabilizing selection in endemic malaria areas).

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