Respuesta :
The goal was to assess the electroencephalogram's (EEG) delta power's (DP) capacity to discriminate between neonates with hypoxia ischemic encephalopathy (HIE) and well-defined outcomes.
In a prospective observational research, prolonged continuous EEG recordings from term infants with HIE during therapeutic hypothermia were studied. The MRI classified a negative outcome as being either death or a major brain injury, whereas a positive outcome was described as being either normal or mildly injured.
By Sarnat grade of encephalopathy at admission, neonates were divided into groups. EEG was divided into epochs that lasted 10 minutes and didn't overlap with any artifacts or seizures. DP was computed and compared between the groups using Wilcoxon rank-sum tests and receiver operating characteristic (ROC) analysis.
A significant distinction between groups was defined as having an area under the ROC curve > 0.7 and a P value of 0.05. Over the majority of time intervals from 9 to 90 hours of life, the favorable result group (n=67) had higher DP than the adverse outcome group (n=28). Early in cooling (9 to 42 hours of life), DP distinguished between newborns with moderate encephalopathy and neonates with severe encephalopathy in terms of outcome groups (63 favorable & 14 bad outcome) (21 to 42 hours of life). After 81 hours of life, infants with moderate and severe encephalopathy were divided into outcome groups.
Independent of the extent of encephalopathy at presentation, DP can identify infants with cooled HIE who will have a poor outcome. In neonates with HIE, DP may be a real-time continuous biomarker of developing encephalopathy and brain damage/death.
Learn more about hypoxia ischemic encephalopathy (HIE): https://brainly.com/question/28205500
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