Low C-peptide levels
When the body produces endogenous insulin, it first forms a bigger molecule called proinsulin, which is composed of two molecules: insulin and C-peptide. Proinsulin is split into equal amounts of insulin and C-peptide during the production of insulin. Since proinsulin does not need to be cleaved in order to make C-peptide, there is none when exogenous insulin is administered into the body. When insulin delivery is the cause of hypoglycemia, the C-peptide levels are low.
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