The novel mechanisms for the regulation of epidermal growth factor receptor endocytosis are revealed by protein kinase A inhibition. So this is a correct statement.
The receptor tyrosine kinases known as the ERBB family, which includes the epidermal growth factor receptor (EGFR), play crucial roles in both healthy physiological states and malignant situations.
The extracellular and intracellular domains of the receptor tyrosine kinases undergo dynamic conformational changes when they contact their ligands, which causes the transphosphorylation of tyrosine residues in the C-terminal regulatory domain.
These act as docking sites for molecules that come after them and cause metastasis, invasion, proliferation, and the avoidance of apoptosis, all of which are crucial for the cancer phenotype.
Therefore, the statement is correct.
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