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SCD is caused by a faulty gene known as the sickle cell gene. Sickle cell disease patients are born with two sickle cell genes, one from each parent.
What is the aetiology of sickle cell anaemia?
Sickle cell disease (SCD) is a hereditary illness caused by a mutation in both copies of the HBB gene in an individual. This gene encodes a component of haemoglobin, the protein that transports oxygen in red blood cells. Because of the mutation, haemoglobin molecules clump together, resulting in sickle-shaped red blood cells.
Sickle cell disease (SCD) is a single-gene ailment caused by a single base-pair point mutation in the -globin gene that results in the amino acid valine being substituted for glutamic acid in the -globin chain.
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