It is true that Fecal microbiota transplantation (FMT) for CDI treatment in children reduces potential pathogen burden and antimicrobial resistance.
Fecal microbiota transplantation (FMT) also known as stool transplant, intestinal microbiota transplantation or bacteriotherapy is performed through a colonoscopy where the microbiota (healthy bacteria) from the carefully screened donor’s feces is transferred to the colon of the recipient.
Children with Clostridioides difficile infection (CDI) treated with fecal microbiota transplantation (FMT) have lower levels of potential pathogens and genes associated with antimicrobial resistance (AMR), as well as altered microbiota makeup and function. However, the acquisition of some AMR genes post-FMT and the low levels of possible pathogens discovered in donors imply that more research into the screening of donors using metagenomics sequencing prior to FMT is necessary.
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