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One of the two amino acids that has a side chain including the modified carboxyl group, carboxamide, is Asparagine.

Non-essential amino acid aspartic acid (Asp/D) has a carboxyl group in its Rgroup. Oxaloacetate is transaminase to easily create it. At physiological pH, the side chain of aspartic acid has a pKa of 3.9 and is negatively charged.

The side chain of the amino acid cysteine is chemically reactive and capable of forming bonds with other cysteines.

At this location, known as the side chain, each amino acid is joined to a different chemical group. Each amino acid differs from the others due to its side chain, which also gives it a distinctive set of chemical properties. The side chain is frequently referred to as a R group and is represented by the letter R.

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