The Signal recognition particle attached to the ER signal sequence of the newly synthesized protein and ribosome.
The abundant, cytosolic, universally conserved ribonucleoprotein known as the signal recognition particle detects and directs particular proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes. The bacterial plasma membrane or the eukaryotic endoplasmic reticulum membrane must receive signal peptide-bearing proteins in order for them to secrete or insert into membranes.
This is accomplished by the signal recognition particle (SRP), a ribonucleoprotein particle. The cotranslational SRP pathway is extremely helpful in the targeted distribution of membrane and secretory proteins because it reduces the aggregation or misfolding of nascent proteins before they reach their biological destination.
Hence, The Signal recognition particle attached to the ER signal sequence of the newly synthesized protein and ribosome.
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