A pair of opposite angles is supplementary, a quadrilateral ABCD can be inscribed in a circle.
Every circle has an inscribed triangle with any three given angle measurements (summing to 180°, of course), and every triangle can be inscribed in any circle (which is called its circumscribed circle or circumcircle). Every triangle has an incircle, which is a circle that has been inscribed.
A cyclic quadrilateral is one that can be encircled by a circle. If and only if a pair of opposite angles is supplementary, a quadrilateral ABCD can be inscribed in a circle. Because the sum of all the angles is 360 degrees, it is true that one pair of supplementary angles is supplementary if and only if both pairs are supplementary.
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