n
6. Even a gene mutation that is a point mutation, meaning it affects
that nucleotide base, can still make a major change
Consider the below information for normal hemoglobin:
ns)
portion of
Hemoglobin DNA
MRNA
AMINO Acids
Sickle Cell Anemia is caused by a point mutation known as a substitution. Show
what would occur if the first T ("thymine") DNA base in the portion shown above
experienced a mutation with a substitution of A ("adenine").
Sickle Cell Hemoglobin:
CCU-GAC1-GAG
mRNA:
GGA CTC CTC
CCU GAG GAG
Proline-Glutamic Acid-Glutamic Acid
Portion of mutated hemoglobin DNA:
Amino Acids: