in the reaction catalyzed by aconitase, the conversion of citrate to isocitrate is inhibited by fluoroacetate. fluoroacetate is used as a pesticide. why is this an effective pesticide?

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08-11-2022
Chemistry

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in the reaction catalyzed by aconitase, the conversion of citrate to isocitrate is inhibited by fluoroacetate. fluoroacetate is used as a pesticide. why is this an effective pesticide?

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AnnuG AnnuG · Answer 1 · 2022-11-11T10:31:12+01:00

In the reaction catalyzed by aconitase, the conversion of citrate to isocitrate is inhibited by fluoroacetate fluoroacetate is used as a pesticide this an effective pesticide because it inhibit the Krebs cycle

Aconitase catalyzes the reversible isomerization of citrate and isocitrate and it is the second enzyme in the citric acid cycle and which is a series of enzymes catalyst chemical reaction that is crucial to aerobic cellular respiration and the production of ATP and citrate is isomerized by dehydration and rehydration to isocitrate and fluoroacetate is the highly toxic towards the human and other mammals through inhibition of the enzyme aconitase in the tricarboxylic acid cycle and that's why fluoroacetate effective pesticide because it inhibit the Krebs cycle

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