Researchers tracking amino acid changes in a large sequence database of SARS-CoV-2's spike protein discovered a D614G (glycine for aspartic acid) substitution that became the predominant polymorphism globally over time.
In animal and in vitro tests, viruses with the G614 polymorphism replicate better, bind to ACE-2 more tightly, and have higher levels of replication and transmissibility when compared to viruses with the D614 polymorphism [12,13]. [14] There is no evidence that the G614 mutation affects the binding of anti-spike antibodies or increases hospitalization risk [11]. There are now many SARS-CoV-2 lineages in circulation that carry it,
using a web search engine, find an article from a reputable source, published within the past six months, that reports on the risk coming from inside the organization compared to the risk coming from outside the organization. if the article notes that this relative risk is changing, how is it changing and to what is the change attributed?
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