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The recommended course of treatment for TCA toxicity is sodium bicarbonate. Through the creation of an alkalosis and a sodium load, this serves to enhance cardiac conduction.
Tricyclic antidepressants induce toxicity in what ways?
TCAs are largely metabolized by and their metabolism may be affected by the enzyme inducers and inhibitors of this pathway. The main substance or one of its metabolites may be toxic. The unbound percentage of TCA may rise in cases of respiratory or metabolic acidosis, which might intensify the negative consequences.
Dry mouth, hazy vision, dilated pupils, sinus tachycardia, pyramidal neurological symptoms, and sleepiness are the most prevalent clinical characteristics.
If an overdose results in respiratory depression, an acidosis, which decreases protein binding, and a rise in the quantity of unbound tricyclic, these effects may also occur.
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