Because securin was not ubiquitinated by the anaphase-promoting complex/cyclosome (apc/c), the cohesin complex continued to exist, preventing the cell from entering anaphase.
When sister chromatids are segregated to opposing spindle poles during the metaphase-to-anaphase transition, Separase helps to release cohesins from the chromosome by breaking down Securin, which is broken down by the anaphase-promoting complex or cyclosome.
We demonstrate that yeast securin Pds1p is present in meiotic nuclei and is destroyed at the beginning of each meiotic division by analyzing the mechanisms that start anaphase in meiotic division.
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