Cells that are in the prometaphase of mitosis are prone to arrest.
During prophase, the nuclear membrane separates, the nucleolus disappears, and the chromosomes condense.
The nuclear envelope separates during the beginning of mitosis as a result of cyclin-dependent kinase. Phosphorylation of INM proteins modifies their interactions with chromatin. Nuclear envelope collapse is necessary for sister chromatid segregation.
The nucleus is encircled by a double membrane known as the nuclear envelope. The largest single organelle in a cell is the nucleus.. The nuclear envelope separates the contents of the nucleus from the outside of the cell. The organism's genes are found on chromosomes.
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