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Two sample t-test is used when the two samples of the data are statistically independent and the paired t-test is used, when data is in the form of matched pairs

The two-sample t-test defined as the method used to test whether the unknown population means of two groups are equal. The two sample t-test is also called independent samples t-test. Because the two samples of the data are statistically independent.

A paired t-test is used to find the difference between two variables usually separated by time for the same subject. By using the paired t-test  we can find the mean difference between pairs of measurements is zero or not. So  paired t-test is used, when data is in the form of matched pairs

Hence, two sample t-test is used when the two samples of the data are statistically independent and the paired t-test is used, when data is in the form of matched pairs

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