The levels of oxaloacetate and citrate in the citric acid cycle will increase if pyruvate oxidation is prevented, whereas citrate levels will fall.
In the citric acid cycle, oxaloacetate interacts with acetyl-CoA to produce citrate, a reaction that is catalyzed by citrate synthase. Gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis are further processes in which it participates. Another effective complex II inhibitor is oxaloacetate.
Oxaloacetate decarboxylase FAHD1 depletion causes human endothelial cells to age and impairs mitochondrial electron transport.
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