R-strain cells and heat-killed S-strain cells individually did not kill the cells because R-strain was non-virulent and the virulent S-strain lost its virulence due to being killed by heat. But when both were injected simultaneously in the cells, some transformation took place from heat-killed S-strain to the R-strain and the R-strain became virulent and killed the cells.
Virulence is the ability of a pathogen to cause harm to the host cell. It is a measure of the degree of capability. In Latin, the meaning of the word virulence is full of poison.
Transformation is the process of uptake of exogenous DNA which is not covered by an cell membrane or envelope.
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