A spontaneous point mutation may be caused during dna replication when the enzyme DNA Polymerase puts the wrong base in a newly-synthesized strand.
Point mutations are changes in the genetic sequences of DNA where only one nucleotide base has been mutated. This can be of several types like addition, deletion, insertion, etc. The example of disease caused by point mutation is sickle cell anemia.
DNA polymerase is the enzyme that forms anew strand of DNA from an existing DNA template strand. Hence it is also called DNA dependent DNA polymerase. The enzyme has different types in prokaryotes as well as eukaryotes.
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