Colony-stimulating factor (CSF) is effective treatment of cyclic neutropenia. Rare blood disorder which is caused by low levels of neutrophils.
Neutrophils are vital to fight the infection by surrounding and destroying the bacteria that enter the body.
CyN is rare. There are an estimated 1-2 cases per 1 million people worldwide
Causes –
1. Mutations
2. Low levels of neutrophils
3. Cell do not perform correctly
The colony-stimulating factors (CSFs) are hematopoietic growth factors (HGFs) involved in regulation of the formation of nonlymphoid blood cells.
Colony-stimulating factors) are secreted glycoproteins that bind to the receptor proteins on the surfaces of hematopoietic stem cells this activates the intracellular signaling pathways causing the cells to proliferate and differentiate into a specific kind of blood cell which is white blood cell
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