a medical technician looks up from the microscope and says to his supervisor, "i think we have a case of hyperlipogenesis here. " what would this information tell the physician about the patient whose tests the technician just analyzed?

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15-11-2022
Medicine

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a medical technician looks up from the microscope and says to his supervisor, "i think we have a case of hyperlipogenesis here. " what would this information tell the physician about the patient whose tests the technician just analyzed?

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tutorconsortium126 tutorconsortium126 · Answer 1 · 2022-11-19T05:24:16+01:00

De novo lipogenesis is the synthesis of fatty acids from non-lipid substrates such as carbohydrates, with glucose serving as the primary substrate.

What is Regulation of lipogenesis ?

Several dietary and hormonal factors, such as insulin, influence lipogenesis in adipocytes. Insulin promotes the expression of GLUT4 receptors. This increases adipocyte glucose uptake and activates pyruvate dehydrogenase. In the presence of sufficient glucose, insulin increases the activity of acetyl Co-A carboxylase and other enzymes involved in carbon chain elongation.

A carbohydrate-rich diet stimulates lipogenesis in adipocytes, whereas fasting inhibits it. Glucose promotes lipogenesis by increasing insulin secretion and activating several lipogenic genes.

Growth hormone, in contrast to insulin, inhibits lipogenesis in adipocytes both directly by downregulating fatty acid synthase and indirectly by decreasing adipocyte sensitivity to insulin action. Leptin also influences lipogenesis in adipocytes, possibly by influencing the neural pathways that connect the hypothalamus to the WAT. Leptin is discussed further in the section 'Leptin.'

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