which of the following is true about nonsynonymous substitutions in a gene coding for a protein? they result in the replacement of an amino acid in the protein. they may be neutral. they may be beneficial they may be deleterious.

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The correct answer is option (A) Nonsynonymous substitutions in a gene coding for a protein result in the replacement of an amino acid in the protein.

A nucleotide mutation known as a nonsynonymous substitution modifies the protein's amino acid sequence. Different from synonymous substitutions, which are (sometimes) quiet mutations and do not change the amino acid sequences, are nonsynonymous substitutions. Nonsynonymous substitutions are subject to natural selection because they cause a biological change in the organism.

The Ka/Ks ratio can be calculated by comparing nonsynonymous substitutions at one locus to synonymous substitutions at the same locus. This ratio is used to gauge how quickly gene sequences are evolving. Because a Ka/Ks ratio, 1 is a defining characteristic of sequences that are being restricted to code for proteins, a gene can be assumed to be functional if it contains lower levels of nonsynonymous than synonymous nucleotide substitution.

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The correct response is option (A), which states that when a protein-coding gene is altered, an amino acid in the resulting protein is replaced.

A nonsynonymous substitution, a type of nucleotide mutation, alters the amino acid sequence of the protein. Different from synonymous substitutions, which are (occasionally) quiet changes and do not modify the amino acid sequences, are nonsynonymous substitutions. Natural selection is applicable to nonsynonymous changes since they alter the organism's biology.

By comparing nonsynonymous changes at one locus to synonymous substitutions at the same locus, the Ka/Ks ratio can be computed. This ratio is used to determine the rate of evolution of gene sequences. Because a Ka/Ks ratio of 1 distinguishes sequences that are dedicated to coding,

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