Respuesta :
The nurse is caring for a client who is diagnosed with cirrhosis. ALT and AST are serum laboratory value(s) will the nurse expects to be abnormal.
Enzymes seep into the bloodstream as a result of toxic insult, ischemia injury, or hepatocyte necrosis. However, the serum ALT level only moderately corresponds with hepatic inflammation in chronic liver illnesses such as cirrhosis and hepatitis C.
Apoptosis (programmed cell death) and necrosis both contribute to the death of liver cells in hepatitis C. As they deteriorate, hepatocytes that undergo apoptosis are likely to produce less AST and ALT.
This likely explains why, despite the evidence of inflammation on liver biopsy, at least one-third of hepatitis C virus-infected patients continue to have normal serum ALT levels.
Cirrhotic patients frequently have normal or barely increased blood AST and ALT values. As a result, the sensitivity of AST and ALT in detection.
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