When a patient with low urine output is administered flucytosine 37 mg/kg every 6 hours, the nurse would predict that this will have an impact on renal function first.
In individuals with renal failure, flucytosine builds up, potentially leading to hazardous serum amounts. 90% of the dosage is eliminated in urine unaltered. In renal insufficiency, dose changes can be done according to the decline in creatinine clearance.
Estimating the glomerular filtration rate (GFR) & looking for proteinuria are the clinical tests that are most useful for determining how well the kidneys are functioning (albuminuria). The glomerular filtration rate is the most accurate overall measure of glomerular function (GFR).
When peak blood levels of flucytosine are >25.0 mcg/mL, the majority of people respond to it at its best.
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