A chromosome with an inversion can pair with a homologous chromosome during meiosis, and one of the chromosomes creates a loop.
A unique variety of mutation known as an inversion involves the 180-degree flipping of a segment of chromosomal DNA. A chromosome must have two breaks for an inversion to happen; after the region between the breaks inverts, the ends of the region rejoin the remainder of the chromosome. Contrary to pericentric inversions, which do contain a centromere, paracentric inversions do not have a centromere in the inverted region.
Hence, inversion pair of homologous chromosome create loop.
To know more about Homologous chromosome.
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