loss of heterozygosity, which often results in progression toward cancer, refers to which of these? please choose the correct answer from the following choices, and then select the submit answer button. answer choices the loss of the tumor-suppressor gene wild-type allele when the cell is heterozygous for a recessive allele the appearance of an abnormal trait in an individual cell or organism that is heterozygous for that trait the gain of a wild-type allele for a tumor-suppressor gene when the cell is homozygous for a recessive mutation at this locus a mutation in a tumor-suppressor gene when the cell is heterozygous at another tumor-suppressor gene locus

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06-12-2022
Biology

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loss of heterozygosity, which often results in progression toward cancer, refers to which of these? please choose the correct answer from the following choices, and then select the submit answer button. answer choices the loss of the tumor-suppressor gene wild-type allele when the cell is heterozygous for a recessive allele the appearance of an abnormal trait in an individual cell or organism that is heterozygous for that trait the gain of a wild-type allele for a tumor-suppressor gene when the cell is homozygous for a recessive mutation at this locus a mutation in a tumor-suppressor gene when the cell is heterozygous at another tumor-suppressor gene locus

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contexto1212 contexto1212 · Answer 1 · 2022-12-09T04:26:16+01:00

Loss of heterozygosity (LOH) is a form of genetic mutation that results in the loss of one normal copy of a gene or a set of genes. Loss of heterozygozity can lead to the development of cancer in some circumstances.

LOH is a typical kind of allelic imbalance in which a heterozygous somatic cell becomes homozygous because one of the two alleles is lost. This kind of chromosomal instability is sufficient to confer selective growth advantage and has been identified as a primary cause of cancer.

When a cancer-producing gene that is heterozygous becomes exposed due to deletion, mutation, recombination, uniparental disomy, or chromosomal aberration, this is referred to as loss of heterozygosity.

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