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The Supremacy Clause was used by the U.S. Supreme Court for the first time in the 1796 case, Ware v. Hylton.

The United States Constitution's Supremacy Clause declares that the federal laws adopted in accordance with the Constitution, and treaties signed in accordance with its authority are the "supreme Law of the Land" and supersede any conflicting state laws. According to its provisions, state constitutions are subservient to the supreme law and state courts are obligated by it. However, federal acts and treaties must be within the bounds of the Constitution; that is, they must be in accordance with the enumerated powers of the federal government and must not violate other constitutional restraints on federal power, such as the Bill of Rights. Of particular significance is the Tenth Amendment to the United States Constitution, which stipulates that the federal government has only those powers granted to it by the Constitution.

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