It is a way for the body to get rid of unwanted or abnormal cells. Cancer cells interfere with the process of programmed cell death. Also known as apoptosis.
Apoptosis is mediated by proteolytic enzymes known as caspases that cause cell death by cleaving certain proteins in the cytoplasm and nucleus. All cells contain inactive precursors of caspases known as procaspases. These procaspases are usually triggered by cleavage by other caspases, resulting in a proteolytic caspase cascade. Mechanisms of cell death in disease states. Extreme stress, which is usually an external stress such as a bacterial infection or an infarction when the blood supply to part of an organ is cut off, can rapidly destroy cells.
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