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The X chromosome scenarios accurately describe how a particular gametic mutation might change the sex ratio in the offspring of a childhood cancer survivor.
A decrease in the frequency of male births can indicate that a recessive lethal gametic mutation has been introduced into the maternal X chromosome.
The two main cell types seen in eukaryotic species are germ and somatic. Both types of cells can experience mutations. A mutation is referred to as a germinal mutation if it occurs in a germ cell. Because gametes develop from germ cells, some gametes will carry the mutation, and when the person successfully mates, they will pass it on to the following generation. Germinal mutations are typically not expressed in the person carrying the mutation. . It would only become apparent if it had a negative (or positive) impact on gamete production. All non-germline tissues are derived from somatic cells. Somatic mutations are changes that occur in somatic cells. The mutations are not sexually transmitted to the following generation because they do not develop in gametes-producing cells.
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