The mucosa layer of the gut wall is where the endocrine or hormone-secreting cells of the gastrointestinal system are found.
Specialized cells of the digestive system and pancreas having an endocrine role are called enteroendocrine cells. In reaction to diverse stimuli, they create gastrointestinal hormones or peptides that are then released into the circulation for systemic effects, spread as local messengers, or are sent to the enteric nervous system to trigger neural responses. The mucosa is the digestive system's innermost layer. It encircles the lumen of the tract and is in direct touch with food that has been digested (chyme). The mucosa is made up of three layers: the connective tissue-rich lamina propria; the epithelium, which is where the majority of digestive, absorptive, and secretory functions take place.
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