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The transmission of germ-line mutations to an organism's progeny occurs during sexual reproduction and occurs in egg cells (sperm or eggs). In non-reproductive cells, somatic mutations take place;

What does the term "somamic mutation" mean?

a DNA mutation that happens after conception. All body cells, excluding the spermatids (and egg), are susceptible to somatic mutations, which are not passed on to offspring. These changes may, but are not always, the root of cancer or other illnesses.

How does a somatic mutation start?

Throughout an individual's life cycle, somatic mutations take place either spontaneously as just a result of mistakes in the DNA repair machinery or as a direct reaction to stress. They are a typical element of aging. Early-stage mutations can alter the gene line and affect organism development by causing mosaicism.

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