Increasing potassium permeability across the membrane makes the membrane more negative.
Since the intracellular environment has a net negative charge and potassium is a positively charged ion, increasing the permeability of the membrane makes it more negative.
The high potassium permeability of the apical membrane promotes potassium secretion and has a repolarizing effect on the apical membrane potential, thereby sustaining ENaC-mediated sodium transport.
A series of voltage-gated potassium channels open and potassium flows out of the cell along an electrochemical gradient. These events rapidly lower the membrane potential and return it to its normal resting state.
Since resting neuronal membranes are highly permeable to K+, the membrane potential is sensitive to changes in extracellular potassium concentration. An increase in extracellular potassium concentration depolarizes neurons.
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