The dietary manipulation that is related most significantly to longevity in animal studies is Caloric Restriction.
The only experimental, non-genetic paradigm that has been shown to lengthen longevity is caloric restriction (CR). It has a wide range of applications and delays aging in most animals, extending their life spans. The usage of CR in humans is of great curiosity, and research on animals may provide insight into its effects.
Studies that restrict calorie intake by giving animals unrestricted access to diluted diets have less influence on longevity than those that have animals consume a smaller amount of food each day while fasting in between meals. This has sparked interest in the function that fasting plays in health and aging as well as the investigation of the health impacts of different fasting regimens.
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