two transcription activators cooperate to recruit a coactivator to a cis-regulatory sequence and activate transcription of a nearby gene. if each of the activators increases the affinity of the coactivator for the reaction site (and therefore the rate of transcription) by 100-fold, how much would you expect the affinity to increase when both activators are bound to dna compared to when none is bound? group of answer choices

Respuesta :

The affinity to increase when both activators are bound to DNA compared to when none is bound is 10,000 folds.

The affinity will increase as an additive effect of both the activators bound to the DNA. Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. Activators are the transcription factors that bind to the enhancer regions, activating the transcription by facilitating the binding of RNA polymerase and/or basal transcription factors to the promoter.

Thus, the affinity to increase when both activators are bound to DNA compared to when none is bound is 10,000 folds.

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